Frans Masereel was born in the Belgian town of Blankenberge on July 31st. He moved to Ghent in 1896, where he began to study at the École des Beaux-Arts in the class of Jean Delvin at the age of 18.  In 1909 he went on trips to England and Germany, which inspired him to create his first etchings and woodcuts. From 1911 on Masereel settled in Paris for four years and then he emigrated to Switzerland, where he worked as a graphic artist for various journals and magazines. His woodcut series, mainly of socio-critical content and of expressionistic form concept, made Masereel internationally known.

In 1921 Masereel returned to Paris, where he painted his famous street scenes, the Montmartre-paintings. He lived for a time in Berlin, where his closest creative friend was George Grosz. After 1925 he lived near Boulogne-sur-Mer, where he painted predominantly coast areas, harbour views, and portraits of sailors and fishermen. During the 1930s the number of illustrated books and single woodcuts decreased. In 1940 he fled from Paris and lived in several cities in Southern France.

At the end of World War II Masereel was able to resume his artistic work and produced woodcuts and paintings. After 1946 he worked for several years as a teacher at the Hochschule der Bildenden Künste Saar in Saarbrücken. In 1949 Masereel settled in Nice. His greatest work is generally said to be the wordless graphic novel Mon Livre d'Heures (Passionate Journey). He completed over 20 other wordless novels in his career. Masereel's woodcuts strongly influenced the work of Lynd Ward and later graphic artists such as Clifford Harper and Eric Drooker. There is now a Frans Masereel Centre (Frans Masereel Centrum for Graphix) in the small village of Kasterlee in Belgium.